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Early-onset cancers developing before the age of 50 have dramatically increased around the world, with this drastic rise beginning around 1990.
References:
https://www.eurekalert.org/news-releases/963907
https://www.nature.com/articles/s41571-022-00672-8
https://www.cdc.gov/niosh/topics/exposome/default.html#:~:text=The%20exposome%20can%20be%20defined%20as%20the%20measure,and%20includes%20insults%20from%20environmental%20and%20occupational%20sources.