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Xylazine is a veterinary drug newly found in illicit opioid supply that is resistant to naloxone. No antidote exists for xylazine.
References:
https://www.eurekalert.org/news-releases/1032989
https://www.cmaj.ca/content/196/4/E133
https://www.cdc.gov/drugoverdose/deaths/other-drugs/xylazine/faq.html